Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.

Abstract

FSH stimulation of granulosa cells (GCs) results in increased hypoxia-inducible factor (HIF)-1alpha protein levels and HIF-1 activity that is necessary for up-regulation of certain FSH target genes including vascular endothelial growth factor. We report that the role of the phosphatidylinositol (PI)-3-kinase/AKT pathway in increasing HIF-1alpha protein in… (More)
DOI: 10.1210/en.2008-0850

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@article{Alam2009RoleOT, title={Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone.}, author={Hena Alam and Jennifer Weck and Evelyn T Maizels and Youngkyu Park and Eun Jig Lee and Margaret Ashcroft and Mary E Hunzicker-Dunn}, journal={Endocrinology}, year={2009}, volume={150 2}, pages={915-28} }