Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.

@article{Radic1991RoleOT,
  title={Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.},
  author={Zoran Radic and Elsa Reiner and Palmer Taylor},
  journal={Molecular pharmacology},
  year={1991},
  volume={39 1},
  pages={98-104}
}
Propidium has been demonstrated in previous studies to be a selective ligand for the peripheral anionic site on acetylcholinesterase (EC 3.1.1.7). Its association with this site can be advantageously monitored by direct fluorescent titration. We have measured the ability of acetylcholine, acetylthiocholine, haloxon [di-(2-chloroethyl)3-chloro-4-methylcoumarin-7-ylphosphate] , and a coumarin derivative (3-chloro-7-hydroxy-4-methylcoumarin) to dissociate propidium from the peripheral anionic site… CONTINUE READING

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