Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys

@article{Karachi2017RoleOT,
  title={Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys},
  author={C. Karachi and Chantal Francois},
  journal={Journal of Neural Transmission},
  year={2017},
  volume={125},
  pages={471-483}
}
Patients with Parkinson’s disease (PD) develop cardinal motor symptoms, including akinesia, rigidity, and tremor, that are alleviated by dopaminergic medication and/or subthalamic deep brain stimulation. Over the time course of the disease, gait and balance disorders worsen and become resistant to pharmacological and surgical treatments. These disorders generate debilitating motor symptoms leading to increased dependency, morbidity, and mortality. PD patients also experience sleep disturbance… CONTINUE READING

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