Role of the p53 family in stabilizing the genome and preventing polyploidization.

@article{Talos2010RoleOT,
  title={Role of the p53 family in stabilizing the genome and preventing polyploidization.},
  author={Flaminia Talos and Ute M. Moll},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={676},
  pages={73-91}
}
Cellular defects resulting in chromosomal instability and aneuploidy are the most common features of human cancers. As a major tumor suppressor and intrinsic part of several cellular checkpoints, p53 contributes to maintenance of the stability of the genetic material, both in quality (ensures faithful replication) and quantity (preservation of diploidy). Although the exact trigger of p53 in case of numerical chromosomal aberrations is unknown, the absence of p53 allows polyploid cells to… CONTINUE READING