Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses.

@article{Giafis2006RoleOT,
  title={Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses.},
  author={Nick Giafis and Efstratios Katsoulidis and Antonella Sassano and Martin S. Tallman and Linda Slanec Higgins and Angel R Nebreda and Roger J Davis and Leonidas C. Platanias},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={6763-71}
}
Arsenic trioxide (As(2)O(3)) induces differentiation and apoptosis of leukemic cells in vitro and in vivo, but the precise mechanisms that mediate such effects are not known. In the present study, we provide evidence that the kinases MAPK kinase 3 (Mkk3) and Mkk6 are activated during treatment of leukemic cell lines with As(2)O(3) to regulate downstream engagement of the p38 mitogen-activated protein kinase. Using cells with targeted disruption of both the Mkk3 and Mkk6 genes, we show that As(2… CONTINUE READING