Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

Abstract

Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker association analyses were assessed under an allelic model with… (More)
DOI: 10.1093/jnci/djt183

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