Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.

@article{Mogilenko2009RoleOT,
  title={Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.},
  author={Denis A. Mogilenko and Ella B. Dizhe and Vladimir S. Shavva and Ivan A. Lapikov and Sergey V Orlov and Andrey P Perevozchikov},
  journal={Biochemistry},
  year={2009},
  volume={48 50},
  pages={
          11950-60
        }
}
The expression of the apolipoprotein A-I gene (apoA-I) in hepatocytes is repressed by pro-inflammatory cytokines such as IL-1beta and TNFalpha. In this work, we have demonstrated that treatment of HepG2 human hepatoma cells with chemical inhibitors for JNK, p38 protein kinases, and NFkappaB transcription factor abolishes the TNFalpha-mediated inhibition of human apoA-I gene expression in HepG2 cells. In addition, we have shown that TNFalpha decreases also the rate of secretion of apoA-I protein… CONTINUE READING
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