Role of the mucins in pathogenesis of COPD: implications for therapy

  title={Role of the mucins in pathogenesis of COPD: implications for therapy},
  author={Federica Lo Bello and Antonio Ieni and Philip Michael Hansbro and Paolo Ruggeri and Antonino Di Stefano and Francesco Nucera and Irene Coppolino and Francesco Monaco and Giovanni Tuccari and Ian M. Adcock and Gaetano Caramori},
  journal={Expert Review of Respiratory Medicine},
  pages={465 - 483}
ABSTRACT Introduction: Evidence accumulated in the last decade has started to reveal the enormous complexity in the expression, interactions and functions of the large number of different mucins present in the different compartments of the human lower airways. This occurs both in normal subjects and in COPD patients in different clinical phases and stages of severity. Areas covered: We review the known physiological mechanisms that regulate mucin production in human lower airways of normal… 
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