Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells.

@article{Zhang2012RoleOT,
  title={Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells.},
  author={Liang Zhang and Jing Yang and Jianfei Qian and Haiyan Li and Jorge E Romaguera and Larry W. Kwak and Miles Wang and Qing Yi},
  journal={Blood},
  year={2012},
  volume={120 18},
  pages={3783-92}
}
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma frequently involved in the lymph nodes, bone marrow, spleen, and gastrointestinal tract. We examined the role of IL-6 in MCL. Human MCL cells expressed the membrane gp130 and soluble gp80, and some of them also secreted IL-6. Neutralizing autocrine IL-6 and/or blocking IL-6 receptors in IL-6(+)/gp80(+) MCL cells inhibited cell growth, enhanced the rate of spontaneous apoptosis, and increased sensitivity to chemotherapy… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 36 references

Multiple myeloma.

The New England journal of medicine • 2011

Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society • 2010

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

H Lee, J Deng, M Kujawski
Nat Med • 2010

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