Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis.

@article{Upton2007RoleOT,
  title={Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis.},
  author={Anna M. Upton and John D McKinney},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 12},
  pages={3973-82}
}
Catabolism of odd-chain-length fatty acids yields acetyl-CoA and propionyl-CoA. A common pathway of propionyl-CoA metabolism in micro-organisms is the methylcitrate cycle, which includes the dedicated enzymes methylcitrate synthase (MCS), methylcitrate dehydratase (MCD) and methylisocitrate lyase (MCL). The methylcitrate cycle is essential for propionate metabolism in Mycobacterium tuberculosis. Unusually, M. tuberculosis lacks an MCL orthologue and this activity is provided instead by two… CONTINUE READING