Role of the membrane localization domain of the Pseudomonas aeruginosa effector protein ExoU in cytotoxicity.

@article{Veesenmeyer2010RoleOT,
  title={Role of the membrane localization domain of the Pseudomonas aeruginosa effector protein ExoU in cytotoxicity.},
  author={Jeff L. Veesenmeyer and Heather B. Howell and Andrei S. Halavaty and Sebastian Ahrens and W. French Anderson and Alan R Hauser},
  journal={Infection and immunity},
  year={2010},
  volume={78 8},
  pages={
          3346-57
        }
}
ExoU is a potent effector protein that causes rapid host cell death upon injection by the type III secretion system of Pseudomonas aeruginosa. The N-terminal half of ExoU contains a patatin-like phospholipase A(2) (PLA(2)) domain that requires the host cell cofactor superoxide dismutase 1 (SOD1) for activation, while the C-terminal 137 amino acids constitute a membrane localization domain (MLD). Previous studies had utilized insertion and deletion mutations to show that portions of the MLD are… CONTINUE READING

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