Role of the membrane (M) protein in endogenous inhibition of in vitro transcription by vesicular stomatitis virus.

@article{Carroll1979RoleOT,
  title={Role of the membrane (M) protein in endogenous inhibition of in vitro transcription by vesicular stomatitis virus.},
  author={Anthony R. Carroll and Robert Richard Wagner},
  journal={Journal of virology},
  year={1979},
  volume={29 1},
  pages={
          134-42
        }
}
An endogenous transcriptase inhibitor active at high concentrations of vesicular stomatitis (VS) virus was present in trypsinized whole virions but was absent from ribonucleoprotein cores containing only the L, N, and NS proteins. Poly(L-glutamic acid) effectively reversed the transcriptase inhibition. Transcription under noninhibited, inhibited, and poly(L-glutamic acid)-reversed conditions did not appear to greatly affect the nature of the RNA transcription product. The VS virion matrix (M… CONTINUE READING

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