Role of the melatonin system in the control of sleep: therapeutic implications.

@article{PandiPerumal2007RoleOT,
  title={Role of the melatonin system in the control of sleep: therapeutic implications.},
  author={Seithikurippu R Pandi-Perumal and Venkatramanujan Srinivasan and David Warren Spence and Daniel P. Cardinali},
  journal={CNS drugs},
  year={2007},
  volume={21 12},
  pages={995-1018}
}
The circadian rhythm of pineal melatonin secretion, which is controlled by the suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control of the sleep/wake cycle. Melatonin can influence sleep-promoting and sleep/wake rhythm-regulating actions through the specific activation of MT(1) (melatonin 1a) and MT(2) (melatonin 1b) receptors, the two major melatonin receptor subtypes found in mammals. Both receptors are highly concentrated in the SCN. In diurnal animals… CONTINUE READING
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