Role of the melanin-concentrating hormone neuropeptide in sleep regulation.

  title={Role of the melanin-concentrating hormone neuropeptide in sleep regulation.},
  author={Christelle Peyron and Emilie Sapin and Lucienne L{\'e}ger and Pierre-Herv{\'e} Luppi and Patrice Fort},
  volume={30 11},
Melanin-concentrating hormone (MCH), a neuropeptide secreted by a limited number of neurons within the tuberal hypothalamus, has been drawn in the field of sleep only fairly recently in 2003. Since then, growing experimental evidence indicates that MCH may play a crucial role in the homeostatic regulation of paradoxical sleep (PS). MCH-expressing neurons fire specifically during PS. When injected icv MCH induces a 200% increase in PS quantities in rats and the lack of MCH induces a decrease in… CONTINUE READING


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Localization of hypothalamic GABAergic neurons implicated in paradoxical (REM) sleep regulation and their relationship with MCH neurons. In: 39th annual meeting of the Society for Neuroscience

  • E Sapin, L Leger, A Berod, PA Herman, PH Luppi, C. Peyron
  • 2009
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