Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide.

@article{Passos2009RoleOT,
  title={Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide.},
  author={Giselle Fazzioni Passos and Cl{\'a}udia Pinto Figueiredo and Rui Daniel Prediger and Pablo Pandolfo and Filipe Silveira Duarte and Rodrigo Medeiros and Jo{\~a}o B. Calixto},
  journal={The American journal of pathology},
  year={2009},
  volume={175 4},
  pages={
          1586-97
        }
}
The hallmarks of Alzheimer's disease include the deposition of beta-amyloid (Abeta), neuroinflammation, and cognitive deficits. The accumulation of activated glial cells in cognitive-related areas is critical for these alterations, although little is known about the mechanisms driving this event. Herein we used macrophage inflammatory protein-1alpha (MIP-1alpha(-/-))- or CC-chemokine receptor 5 (CCR5(-/-))-deficient mice to address the role played by chemokines in molecular and behavioral… CONTINUE READING

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