Role of the lncRNA-p53 regulatory network in cancer.

  title={Role of the lncRNA-p53 regulatory network in cancer.},
  author={Ali Zhang and Min Xu and Yin-yuan Mo},
  journal={Journal of molecular cell biology},
  volume={6 3},
Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how lncRNAs serve… CONTINUE READING
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