Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination.

@article{Smith2005RoleOT,
  title={Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination.},
  author={Nicola F Smith and William D. Figg and Alex Sparreboom},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2005},
  volume={1 3},
  pages={429-45}
}
Members of the organic anion transporting polypeptide (OATP) family are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. This review focuses on OATP1B1 and -1B3, which are specifically expressed in the liver and considered to be of particular importance for hepatic drug elimination and drug pharmacokinetics. Recent literature has indicated that inhibition of these transporters may result in drug-drug interactions. Furthermore… CONTINUE READING
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