Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy.

@article{Natarajan1994RoleOT,
  title={Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy.},
  author={Rama Natarajan and NickO. Gonzales and Linda L. Lanting and Janice Nadler},
  journal={Hypertension},
  year={1994},
  volume={23 1 Suppl},
  pages={I142-7}
}
The 12-lipoxygenase pathway is a key mediator of angiotensin II (Ang II)-induced effects in the adrenal cortex. We also recently demonstrated that Ang II increases 12- and 15-lipoxygenase product levels in vascular smooth muscle cells. However, the relation between lipoxygenase activation and Ang II-induced vascular smooth muscle cell hypertrophy is not known. We studied the effects of Ang II and 12-lipoxygenase products on both total cell protein content and the levels of the matrix protein… CONTINUE READING