Role of the leukemia-inhibitory factor gene mutations in infertile women: The embryo-endometrial cytokine cross talk during implantation — a delicate homeostatic equilibrium

@article{Krlkov2008RoleOT,
  title={Role of the leukemia-inhibitory factor gene mutations in infertile women: The embryo-endometrial cytokine cross talk during implantation — a delicate homeostatic equilibrium},
  author={Milena Kr{\'a}l{\'i}{\vc}kov{\'a} and Petr {\vS}{\'i}ma and Zdenĕk Rokyta},
  journal={Folia Microbiologica},
  year={2008},
  volume={50},
  pages={179-186}
}
Locally secreted cytokines of both the embryonic and the endometrial origin control the implantation process. The defects in their signaling that lead to unfavorable environment within the uterus may cause embryo implantation failure. The leukemia inhibitory factor (LIF), interleukin-11 (IL-11) as well as IL-12/IL-15/IL-18 system are regarded to be important signaling vectors. LIF plays an essential role in the preimplantation embryo development and the blastocyst implantation and its gene… 

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References

SHOWING 1-10 OF 72 REFERENCES

Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.

TLDR
The results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.

Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.

Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium/decidua. The independently developing preimplantation blastocyst then becomes dependent

Expression of leukemia inhibitory factor in human endometrium and placenta.

TLDR
Findings suggest that, in humans, LIF plays a role in uterine function during the menstrual cycle, as well as during pregnancy.

Regulation of embryonic implantation.

Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo.

  • C. Stewart
  • Biology
    Molecular reproduction and development
  • 1994
TLDR
Data indicate that the maternal environment plays a crucial role in the development and growth of the pre-implantation embryo, by supplying factors that regulate these processes in the embryo.

Review: The role of leukaemia inhibitory factor in the establishment of pregnancy.

TLDR
It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

Molecular aspects of implantation: In-vitro endometrial secretion of human interleukin for DA cells/ leukaemia inhibitory factor by explant cultures from fertile and infertile women

TLDR
The results suggest an abnormal regulation of HILDA/LIF secretion in such circumstances, and the clinical implication of those data is discussed.

Stage-specific expression of leukaemia inhibitory factor and its receptor in rabbit pre-implantation embryo and uterine epithelium during early pregnancy.

TLDR
The data present here show the stage-specific and dynamic expression patterns of LIF and LIFR, both in embryos and endometrium, during early pregnancy in rabbits, which indicated that LIF might play an important role in the pre-implantation development and subsequent implantation of rabbit embryos.
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