Role of the leukemia-inhibitory factor gene mutations in infertile women: The embryo-endometrial cytokine cross talk during implantation — a delicate homeostatic equilibrium

  title={Role of the leukemia-inhibitory factor gene mutations in infertile women: The embryo-endometrial cytokine cross talk during implantation — a delicate homeostatic equilibrium},
  author={Milena Kr{\'a}l{\'i}{\vc}kov{\'a} and Petr {\vS}{\'i}ma and Zdenĕk Rokyta},
  journal={Folia Microbiologica},
Locally secreted cytokines of both the embryonic and the endometrial origin control the implantation process. The defects in their signaling that lead to unfavorable environment within the uterus may cause embryo implantation failure. The leukemia inhibitory factor (LIF), interleukin-11 (IL-11) as well as IL-12/IL-15/IL-18 system are regarded to be important signaling vectors. LIF plays an essential role in the preimplantation embryo development and the blastocyst implantation and its gene… 

Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women

The presence of aPLs was significantly higher in the study group than in 30 % of a PLs-positives in control infertile patients (p=0.0035) which indicates that the aPLS are elevated in women with LIF gene mutations.

Cytokine networks in the establishment and maintenance of pregnancy

Pregnancy is an immunological compromise geared towards inducing maternal immunopermissiveness that promotes tolerance of the foetal allograft. This process is mediated by an extensive array of

Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study.

The results suggest that in mutation-positive women the idiopathic infertility and endometriosis have a negative impact on the outcome of IVF treatment.

Delineating the prime mover action of progesterone for endometrial receptivity in primates

Progesterone is essential for endometrial receptivity in primates. It is now evident that embryo-derived signal influences implantation stage endometrium under progesterone dominance, and

Defining pregnancy phases with cytokine shift

The present article compartmentalizes and simplifies the concept of immune regulation of pregnancy based on the panoply of activated cytokines using the cytokine profile alterations in immune mediation of pregnancy.

The Roles of Anandamide, Fatty Acid Amide Hydrolase, and Leukemia Inhibitory Factor on the Endometrium during the Implantation Window

The data indicated the important role of the ECS in human fertility, which may promote new strategies for successful implantation and treatments for reproductive diseases.

Association of GSTM1 and GSTT1 gene polymorphisms and in-vitro fertilisation outcome in a population in northern Iran

Abstract Implantation failure is a major limiting step for in-vitro fertilisation (IVF). Embryo implantation is the result of the interaction of the embryo with the endometrium. Oxidative stress (OS)

Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.

It is suggested that LIF participates in placentation through EVT invasion by up-regulating P GE2 production and PGE2 receptor expression in first trimester EVT.

Cytokine Networks and the Regulation of Uterine Function in Pregnancy and Parturition

Current knowledge concerning the impact of cytokines on uterine physiology and pathophysiology is reviewed, finding that perturbations to cytokine signalling are associated with adverse pregnancy outcomes, including miscarriage, pre‐eclampsia, preterm labour and foetal brain injury.

Histidine-rich glycoprotein polymorphism and pregnancy outcome: a pilot study.



Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.

The results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.

Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.

Implantation is the process by which the blastocyst becomes intimately connected with the maternal endometrium/decidua. The independently developing preimplantation blastocyst then becomes dependent

Expression of leukemia inhibitory factor in human endometrium and placenta.

Findings suggest that, in humans, LIF plays a role in uterine function during the menstrual cycle, as well as during pregnancy.

Regulation of embryonic implantation.

Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo.

  • C. Stewart
  • Biology
    Molecular reproduction and development
  • 1994
Data indicate that the maternal environment plays a crucial role in the development and growth of the pre-implantation embryo, by supplying factors that regulate these processes in the embryo.

Review: The role of leukaemia inhibitory factor in the establishment of pregnancy.

It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

Molecular aspects of implantation: In-vitro endometrial secretion of human interleukin for DA cells/ leukaemia inhibitory factor by explant cultures from fertile and infertile women

The results suggest an abnormal regulation of HILDA/LIF secretion in such circumstances, and the clinical implication of those data is discussed.

Stage-specific expression of leukaemia inhibitory factor and its receptor in rabbit pre-implantation embryo and uterine epithelium during early pregnancy.

The data present here show the stage-specific and dynamic expression patterns of LIF and LIFR, both in embryos and endometrium, during early pregnancy in rabbits, which indicated that LIF might play an important role in the pre-implantation development and subsequent implantation of rabbit embryos.