Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells

@article{Flaumenhaft1993RoleOT,
  title={Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells},
  author={Robert Flaumenhaft and Mitsuru Abe and Yasufumi Sato and Kohei Miyazono and John G. Harpel and Carl-Henrik Heldin and Daniel B. Rifkin},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={120},
  pages={995 - 1002}
}
Transforming growth factor beta (TGF-beta) is released from cells in a latent form consisting of the mature growth factor associated with an aminoterminal propeptide and latent TGF-beta binding protein (LTBP). The endogenous activation of latent TGF-beta has been described in co-cultures of endothelial and smooth muscle cells. However, the mechanism of this activation remains unknown. Antibodies to native platelet LTBP and to a peptide fragment of LTBP inhibit in a dose-dependent manner the… CONTINUE READING