Role of the kinesin neck linker and catalytic core in microtubule-based motility

  title={Role of the kinesin neck linker and catalytic core in microtubule-based motility},
  author={Ryan B. Case and Sarah Rice and Cynthia L. Hart and Bernice Ly and Ronald D. Vale},
  journal={Current Biology},
Kinesin motor proteins execute a variety of intracellular microtubule-based transport functions [1]. Kinesin motor domains contain a catalytic core, which is conserved throughout the kinesin superfamily, followed by a neck region, which is conserved within subfamilies and has been implicated in controlling the direction of motion along a microtubule [2] [3]. Here, we have used mutational analysis to determine the functions of the catalytic core and the approximately 15 amino acid 'neck linker… CONTINUE READING

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