Role of the kidney in pathogenesis of hypertension as determined by a study of the effects of bilateral nephrectomy and other experimental procedures on the blood pressure of the dog.

Abstract

0 NE of the difficulties involved in determining experimentally the exact r8le which the kidney plays in the pathogenesis of hypertension has been the impossibility of ablating this organ without introducing the fatal effects of interfering with its normal excretory function. For this reason, it has been impossible to apply the simple experimental procedure of extirpation which has aided so much in the elucidation of the function of other organs. It is, in fact, generally assumed that bilateral nephrectomy causes no change in the blood pressure. However, animals subjected to this procedure in the past have survived for such relatively short periods and were in such poor condition that any conclusion as to the effect of nephrectomy on the blood pressure based on observations of such animals is not convincing.

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Cite this paper

@article{Grollman1949RoleOT, title={Role of the kidney in pathogenesis of hypertension as determined by a study of the effects of bilateral nephrectomy and other experimental procedures on the blood pressure of the dog.}, author={Arthur P. Grollman and E. Eric Muirhead and J C Vanatta}, journal={The American journal of physiology}, year={1949}, volume={157 1}, pages={21-30} }