Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

@article{Gallay1996RoleOT,
  title={Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.},
  author={Philippe A Gallay and V J Stitt and Christina Mundy and Moshe Oettinger and Didier Trono},
  journal={Journal of virology},
  year={1996},
  volume={70 2},
  pages={1027-32}
}
The interaction of the human immunodeficiency virus type 1 (HIV-1) nucleoprotein complex with the cell nuclear import machinery is necessary for viral replication in macrophages and for the establishment of infection in quiescent T lymphocytes. The karyophilic properties of two viral proteins, matrix (MA) and Vpr, are keys to this process. Here, we show that an early step of HIV-1 nuclear import is the recognition of the MA nuclear localization signal (NLS) by Rch1, a member of the karyopherin… CONTINUE READING
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