Role of the intestinal microflora in the formation of DNA and haemoglobin adducts in rats treated with 2-nitrofluorene and 2-aminofluorene by gavage.

@article{Scheepers1994RoleOT,
  title={Role of the intestinal microflora in the formation of DNA and haemoglobin adducts in rats treated with 2-nitrofluorene and 2-aminofluorene by gavage.},
  author={Paul T. J. Scheepers and D D Velders and M J S Steenwinkel and Joost H. M. van Delft and Willie Driessen and M M Stratemans and Robert A. Baan and Jan Pieter R. Koopman and Jan Noordhoek and R. P. Bos},
  journal={Carcinogenesis},
  year={1994},
  volume={15 7},
  pages={1433-41}
}
The role of the intestinal microflora in the metabolic activation of nitroarenes and arylamines was studied in female Wistar rats that received a dose of 1 mmol/kg 2-aminofluorene (2-AF) in sunflower oil by gavage. Another group received the same dose of 2-nitrofluorene (2-NF). A third group of animals was used as controls. Germfree (GF) rats, GF rats with a rat microflora (RM) and GF rats with a human microflora (HM) were treated. After treatment with 2-AF significant differences were observed… CONTINUE READING