Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.

@article{Dumoutier2004RoleOT,
  title={Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.},
  author={Laure Dumoutier and Amel Boudriga Tounsi and Thomas Michiels and Caroline Sommereyns and Sergei V. Kotenko and Jean-Christophe Renauld},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 31},
  pages={32269-74}
}
Interferon (IFN)-lambda 1, -lambda 2, and -lambda 3 are the latest members of the class II cytokine family and were shown to have antiviral activity. Their receptor is composed of two chains, interleukin-28R/likely interleukin or cytokine or receptor 2 (IL-28R/LICR2) and IL-10R beta, and mediates the tyrosine phosphorylation of STAT1, STAT2, STAT3, and STAT5. Here, we show that activation of this receptor by IFN-lambda 1 can also inhibit cell proliferation and induce STAT4 phosphorylation… CONTINUE READING
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