Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis.

@article{Hou2011RoleOT,
  title={Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis.},
  author={Shao-zhen Hou and Ziren Su and Shu-xian Chen and M R Ye and Song Huang and Liang Liu and Hua Zhou and Xiao-Ping Lai},
  journal={Chemico-biological interactions},
  year={2011},
  volume={192 3},
  pages={184-92}
}
Adverse drug reactions (ADR), especially intravenous hemolysis, have largely limited the application of puerarin injections in clinics. This study investigated the underlying mechanisms of puerarin-induced hemolysis. Our results show that puerarin induced concentration-dependent and time-dependent hemolysis when human erythrocytes were incubated in saline solution with more than 2mM puerarin for over 2h. However, incubation in PBS or addition of 1mM of lidocaine to the saline solution… CONTINUE READING
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