Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix.

@article{Ashida1995RoleOT,
  title={Role of the integument in insect defense: pro-phenol oxidase cascade in the cuticular matrix.},
  author={Masaaki Ashida and Paul T. Brey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 23},
  pages={10698-702}
}
The cuticle of the silkworm Bombyx mori was demonstrated to contain pro-phenol oxidase [zymogen of phenol oxidase (monophenol, L-dopa:oxygen oxidoreductase, EC 1.14.18.1)] and its activating cascade. The activating cascade contained at least one serine proteinase zymogen (latent form of pro-phenol oxidase activating enzyme). When the extracted cascade components were incubated with Ca2+, the latent form of pro-phenol oxidase activating enzyme was itself activated and, in turn, converted through… CONTINUE READING