Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors.

@article{Baron1996RoleOT,
  title={Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors.},
  author={V{\'e}ronique T Baron and Philippe Gual and Franc Oise Alengrin and E Van Obberghen},
  journal={European journal of biochemistry},
  year={1996},
  volume={241 1},
  pages={186-92}
}
Basic polymers such as polylysine have been found to activate insulin receptor autophosphorylation and kinase activity toward substrates. It was suggested that acidic receptor domains may be involved in the interaction of the receptor with these basic effectors. In a previous study, we have shown that the receptor acid-rich C-terminal sequence, including… CONTINUE READING