Role of the innate immune response and tumor immunity associated with simian virus 40 large tumor antigen.

@article{Lowe2010RoleOT,
  title={Role of the innate immune response and tumor immunity associated with simian virus 40 large tumor antigen.},
  author={Devin B. Lowe and Michael H. Shearer and Joel F. Aldrich and Richard E. Winn and Cynthia A. Jumper and Ronald C. Kennedy},
  journal={Journal of virology},
  year={2010},
  volume={84 19},
  pages={10121-30}
}
We examined properties of the innate immune response against the tumor-specific antigen simian virus 40 (SV40) large tumor antigen (Tag) following experimental pulmonary metastasis in naive mice. Approximately 14 days after mKSA tumor cell challenge, expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin-2 (IL-2), and RANTES was upregulated in splenocytes harvested from mice, as assessed by flow cytometry and antibody array assays. This response was… CONTINUE READING

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