Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure.

@article{Woolbright2017RoleOT,
  title={Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure.},
  author={Benjamin L. Woolbright and Hartmut Jaeschke},
  journal={Journal of hepatology},
  year={2017},
  volume={66 4},
  pages={
          836-848
        }
}
Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen overdose is the number one cause of acute liver failure and remains a major problem in Western medicine. Administration of N-acetyl cysteine is an effective antidote when given before the initial rise in toxicity; however, many patients present to the hospital after this stage occurs. As such, treatments which can alleviate late-stage acetaminophen-induced acute liver failure are imperative. While the… CONTINUE READING
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Persistent generation of inflammatory mediators after acetaminophen overdose in surviving and nonsurviving patients

  • BL Woolbright, MR McGill, MR Sharpe, H. Jaeschke
  • (abstract). Hepatology 2015;62(Suppl.):500A
  • 2015
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