Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells.

@article{Abreu2018RoleOT,
  title={Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells.},
  author={Rodrigo Abreu and Frederick D. Quinn and Pramod Kumar Giri},
  journal={Blood advances},
  year={2018},
  volume={2 10},
  pages={1089-1100}
}
Upon infection, pathogen and host compete for the same iron pool, because this trace metal is a crucial micronutrient for all living cells. Iron dysregulation in the host is strongly associated with poor outcomes in several infectious diseases, including tuberculosis, AIDS, and malaria, and inefficient iron scavenging by pathogens severely affects their virulence. Hepcidin is the master regulator of iron homeostasis in vertebrates, responsible for diminishing iron export from macrophages during… CONTINUE READING
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