Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin.

@article{Coulton2008RoleOT,
  title={Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin.},
  author={Arthur T. Coulton and Kezia Koka and Sherwin S. Lehrer and Michael A. Geeves},
  journal={Biochemistry},
  year={2008},
  volume={47 1},
  pages={388-97}
}
Tropomyosin (Tm) is an alpha-helical, parallel, two-chain coiled coil which binds along the length of actin filaments in both muscle and non-muscle cells. Smooth and skeletal muscle Tms differ extensively at the C-terminus encoded by exon 9. Replacement of the striated muscle specific exon 9a-encoded C-terminus with that encoded by exon 9d expressed in smooth muscle and non-muscle cells increases the affinity of unacetylated alpha-SkTm for actin [Cho, Y. J., and Hitchcock-Degregori, S. E. (1991… CONTINUE READING

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