Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression.

@article{Ricci2017RoleOT,
  title={Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression.},
  author={Erika Basso Ricci and Simona Ronchetti and Eva Pericolini and Elena Gabrielli and Luigi Cari and Marco Gentili and Elena Roselletti and Graziella Migliorati and Anna Vecchiarelli and Carlo Riccardi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 7},
  pages={3054-3065}
}
The glucocorticoid-induced leucine zipper (GILZ) gene is a pivotal mediator of the anti-inflammatory effects of glucocorticoids (GCs) that are known to regulate the function of both adaptive and innate immunity cells. Our aim was to investigate the role of GILZ in GC-induced inhibition of neutrophil migration, as this role has not been investigated before. We found that GILZ expression was induced by dexamethasone (DEX), a synthetic GC, in neutrophils, and that it regulated migration of these… CONTINUE READING
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