Role of the glucagon receptor COOH-terminal domain in glucagon-mediated signaling and receptor internalization.

@article{Buggy1997RoleOT,
  title={Role of the glucagon receptor COOH-terminal domain in glucagon-mediated signaling and receptor internalization.},
  author={Joseph J. Buggy and R O Heurich and Margit Macdougall and Kevin A. Kelley and James N. Livingston and H Yoo-Warren and A J Rossomando},
  journal={Diabetes},
  year={1997},
  volume={46 9},
  pages={
          1400-5
        }
}
The binding of glucagon to its hepatic receptor is known to result in a number of effects, including the intracellular accumulation of cAMP, the mobilization of intracellular Ca2+, and the endocytosis of glucagon and its receptor into intracellular vesicles. In this study, we begin to define the functional role of the COOH-terminal tail of the human glucagon receptor in glucagon-stimulated signal transduction and receptor internalization. We have created and expressed in Chinese hamster ovary… CONTINUE READING

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