Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats.

@article{Parent1990RoleOT,
  title={Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats.},
  author={Andr{\'e} Parent and Ernesto L Schiffrin and Jean St-Louis},
  journal={American journal of obstetrics and gynecology},
  year={1990},
  volume={163 1 Pt 1},
  pages={229-34}
}
Responses to adrenergic agents were measured on rings of mesenteric, artery of nonpregnant and pregnant rats at 21 days' gestation. In tissues from pregnant rats, norepinephrine, and phenylephrine were less sensitive than in rings from nonpregnant animals; maximum responses were not affected. The effect of isoproterenol was not modified in tissues from pregnant rats. The presence of endothelium in tissue rings was evaluated as fractional relaxation to acetylcholine. Sensitivity to phenylephrine… CONTINUE READING