Role of the endothelial glycocalyx in dromotropic, inotropic, and arrythmogenic effects of coronary flow.

@article{Rubio2000RoleOT,
  title={Role of the endothelial glycocalyx in dromotropic, inotropic, and arrythmogenic effects of coronary flow.},
  author={Rafael Rubio and Guillermo A Ceballos},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 1},
  pages={H106-16}
}
Coronary flow regulates cardiac functions, and it has been suggested that endothelial membrane glycosylated proteins are the primary shear stress mechanosensors. Our hypothesis was that if these proteins are the sensors for flow, then intracoronary perfusion of lectins or specific antibodies should differentially depress coronary flow-enhanced responses of different parenchymal cell types such as auricular-ventricular (A-V) nodal cells (dromotropic effect), contractile myocytes (inotropic… CONTINUE READING
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