Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles.

@article{Saeed2011RoleOT,
  title={Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles.},
  author={Mohsan Saeed and Ryosuke Suzuki and Noriyuki Watanabe and Takahiro Masaki and Mitsunori Tomonaga and Amir Muhammad and Takanobu Kato and Yoshiharu Matsuura and Haruo Watanabe and Takaji Wakita and Tetsuro Suzuki},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 43},
  pages={
          37264-73
        }
}
Viral infections frequently cause endoplasmic reticulum (ER) stress in host cells leading to stimulation of the ER-associated degradation (ERAD) pathway, which subsequently targets unassembled glycoproteins for ubiquitylation and proteasomal degradation. However, the role of the ERAD pathway in the viral life cycle is poorly defined. In this paper, we demonstrate that hepatitis C virus (HCV) infection activates the ERAD pathway, which in turn controls the fate of viral glycoproteins and… CONTINUE READING
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