Role of the endocannabinoid system in the neuroendocrine responses to inflammation.

  title={Role of the endocannabinoid system in the neuroendocrine responses to inflammation.},
  author={Andrea de Laurentiis and Hugo A Araujo and Val{\'e}ria Rettori},
  journal={Current pharmaceutical design},
  volume={20 29},
A few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids are synthesized in a broad class of cell types, including those in the brain and the immune system; they bind to cannabinoid G-protein-coupled receptors, having profound effects on a variety of behavioral, neuroendocrine and autonomic functions. The coordinated neural, immune, behavioral and… 
Identification of an endocannabinoid system in the rat pars tuberalis—a possible interface in the hypothalamic-pituitary-adrenal system?
The results suggest that the EC system at the hypothalamo-hypophysial interface affects both the CRF-containing nerve fibers and the corticotrope cells in the adenohypophysis.
Signaling pathways to and from the hypophysial pars tuberalis, an important center for the control of seasonal rhythms.
  • H. Korf
  • Biology
    General and comparative endocrinology
  • 2018
Cannabinoid Receptor 1 and 2 Signaling Pathways Involved in Sepsis
The role of CB1 in the cardiovascular system is discussed, which is one of the biological systems that are strongly affected by sepsis and septic shock, and CB2 activation, which exerts anti-inflammatory activities with potential benefit in sepsi is reviewed.
Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010.
This review is an account of granted CB2R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation®.
Profiling Rat Brain Monoacylglycerol Lipase Activity Using an Ammonia-Adduct Enhanced Selected Ion Monitoring Liquid-ChromatographyPositive Electrospray Ionization Mass Spectrometry Assay
The SIM LC / +ESI / MS method is shown to be useful for in-vitro brain evaluation of inhibitory potency of MAGL and fatty acid amide hydrolase (FAAH) inhibitors and for in thevivo brain assessment for target engagement studies.
Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines
A series of 2,4,6-trisubstituted 1,3,5-triazines with piperazinylalkyl or 1,2-diethoxyethane (PEG2) chains as CB2 agonists were designed and synthesised, all of which were predicted to be considerably more polar than typical cannabinoid ligands.
The review analyzes the change of the existing paradigm of high radioresistance of the nervous system according tothe results of the study of neuropsychiatric disorders in in the aftermath of the


The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis.
The Role of the Endocannabinoid System in the Regulation of Hypothalamic‐Pituitary‐Adrenal Axis Activity
  • D. Cota
  • Biology
    Journal of neuroendocrinology
  • 2008
Observations suggest that alterations of the endocannabinoid tone might be associated with the development of stress‐related diseases, including anxiety, depression and obesity.
Expression and function of endocannabinoid receptors in the human adrenal cortex.
Anandamide inhibited basal release and stimulated release of adrenocortical steroids (corticosterone and aldosterone) and this effect was reversed by CB1 antagonist (SR141716A); therefore, the endocannabinoid system at the level of the adrenal, can directly influence adrenOCortical steroidogenesis.
Alcohol and endocannabinoids: Neuroendocrine interactions in the reproductive axis
Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior.
Overall, it appears that bidirectional interactions characterize the relationship between endocannabinoids and gonadal hormones, with endoc cannabinoidoids down-regulating hypothalamic-pituitary-gonadal activity and Gonadal hormones modulating protein expression in the endoc Cannabinoid system.
Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance.
  • D. Finn
  • Biology, Psychology
  • 2010
Functional Interactions between Stress and the Endocannabinoid System: From Synaptic Signaling to Behavioral Output
The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress.
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.