Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450.

@article{Taniguchi1984RoleOT,
  title={Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450.},
  author={Hisaaki Taniguchi and Yoshio Imai and Reiko Sato},
  journal={Archives of biochemistry and biophysics},
  year={1984},
  volume={232 2},
  pages={585-96}
}
Four protein components of the hepatic microsomal electron transfer system, NADPH-cytochrome P-450 reductase, cytochrome P-450, NADH-cytochrome b5 reductase, and cytochrome b5, all purified from liver microsomes of phenobarbital-pretreated rabbits, were co-reconstituted into liposomes of egg yolk phosphatidylcholine. The electron transfer rates between the four protein components were measured directly by the stopped-flow method with the reconstituted systems of different compositions, and the… CONTINUE READING
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