Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection.

@article{Donnenberg1993RoleOT,
  title={Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection.},
  author={Michael S. Donnenberg and Carol O. Tacket and Stephen P. James and Genevieve A. Losonsky and James P Nataro and Steven S Wasserman and J. Kaper and Myron M. Levine},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 3},
  pages={1412-7}
}
Enteropathogenic Escherichia coli (EPEC) infections are a leading cause of infant diarrhea in developing countries. Recently eaeA, a gene necessary for the characteristic intimate attachment of EPEC to epithelial cells in tissue culture, was described. We conducted a randomized, double-blind study to determine the role of the eaeA gene in human EPEC infection. 11 adult volunteers ingested 2 x 10(10) colony-forming units of O127:H6 EPEC strain E2348/69, and an equal number received the same dose… CONTINUE READING

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