Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation.

@article{Melikyan2000RoleOT,
  title={Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation.},
  author={Grigory B. Melikyan and Ruben M. Markosyan and Sofya A. Brener and Yanina Rozenberg and Fredric Cohen},
  journal={Journal of virology},
  year={2000},
  volume={74 1},
  pages={447-55}
}
Fusion between cells expressing envelope protein (Env) of Moloney murine leukemia virus and target cells were studied by use of video fluorescence microscopy and electrical capacitance measurements. When the full-length 632-amino-acid residue Env was expressed, fusion did not occur at all for 3T3 cells as target and only somewhat for XC6 cells. Expression of Env 616*-a construct of Env with the last 16 amino acid residues (617 to 632; the R peptide) deleted from its C terminus to match the… CONTINUE READING

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