Role of the cytochrome P450 enzyme system in veterinary pharmacokinetics: where are we now? Where are we going?

@article{Antonovic2011RoleOT,
  title={Role of the cytochrome P450 enzyme system in veterinary pharmacokinetics: where are we now? Where are we going?},
  author={Leposava Antonovic and Marilyn Martinez},
  journal={Future medicinal chemistry},
  year={2011},
  volume={3 7},
  pages={855-79}
}
Drug metabolism is a core determinant of the dose-effectiveness-toxicity relationship of many compounds. It is also critical to the human food safety assessment of drug residues in the edible tissues of food-producing animals. This article describes the current state of knowledge regarding the role of the cytochrome P450 superfamily of enzymes in determining the metabolic profile of compounds administered to companion animals (e.g., dog and cat) and to food-producing animal species (e.g… CONTINUE READING
5 Extracted Citations
85 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 85 references

Physiologically Based Pharmacokinetic Modeling: Science and Applications

  • M Reddy, RS Yang, ME Anderson, HJ. Clewell
  • 2011

Similar Papers

Loading similar papers…