Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma.

Abstract

BACKGROUND Approximately 8 to 12% of melanoma appears to be inherited in an autosomal dominant form. Although most early stage melanomas can be treated successfully by simple surgical excision, patients with advanced disease are rarely cured even with aggressive chemotherapy and/or immunotherapy. OBJECTIVE There is now compelling evidence that germline… (More)

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