Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

@article{Anderson1977RoleOT,
  title={Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts},
  author={R. Anderson and M. Brown and J. Goldstein},
  journal={Cell},
  year={1977},
  volume={10},
  pages={351-364}
}
  • R. Anderson, M. Brown, J. Goldstein
  • Published 1977
  • Biology, Medicine
  • Cell
  • 125I-labeled and ferritin-labeled low density lipoprotein (LDL) were used as visual probes to study the surface distribution of LDL receptors and to examine the mechanism of the endocytosis of this lipoprotein in cultured human fibrobasts. Light microscopic autoradiograms of whole cells incubated with 125I-LDL at 4 degrees C showed that LDL receptors were widely but unevenly distributed over the cell surface. With the electron microscope, we determined that 60-70% of the ferritin-labeled LDL… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Role of bristle-coated membrane in the uptake of ferritin by rat macrophages.
    • 31
    FUNCTIONS OF COATED VESICLES DURING PROTEIN ABSORPTION IN THE RAT VAS DEFERENS
    • 790
    • PDF
    PINOCYTOSIS IN FIBROBLASTS
    • 278
    • PDF