Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition

  title={Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition},
  author={David E. Comings and Sujihan Wu and Massud Rostamkhani and Matt McGue and William G Lacono and Li S-C Cheng and James P. MacMurray},
  journal={Molecular Psychiatry},
SIR – Heritability estimates for intelligence quotient (IQ) range from 0.50 to 0.80. This makes IQ a suitable target for attempts to identify the specific genes involved. This first such gene to be identified was by Chorney et al. They reported an association between the insulin-like growth factor 2 receptor (IGF2R) gene and IQ. Cholinergic pathways have been widely implicated in cognition and memory, making the respective genes excellent candidate markers for cognitive abilities… CONTINUE READING