Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.

@article{Raoul2008RoleOT,
  title={Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.},
  author={William Raoul and Nicole Keller and Mathieu P Rodero and Francine B{\'e}har-Cohen and Florian Sennlaub and Christophe Combadi{\`e}re},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={198 1-2},
  pages={56-61}
}
We recently showed that subretinal CX3CR1-dependent microglial cell (MC) accumulation may lead to age-related macular degeneration. The fate of MC after engulfing retinal debris is poorly understood. Severe photoreceptor degeneration was observed 40days after exposure to bright light in CX3CR1-deficient but not control mice, and more MCs accumulated in the subretinal space of the former than the latter. To study the fate of subretinal MCs in CX3CR1 competent animals, we used a dystrophic rat… CONTINUE READING