Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats.

@article{KiritsyRoy1990RoleOT,
  title={Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats.},
  author={J A Kiritsy-Roy and Jeffrey B. Halter and Sharon M Gordon and Mairin Smith and L. Cass Terry},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={255 1},
  pages={154-60}
}
These studies were undertaken to examine the contribution of central nervous system mechanisms to the cardiovascular and sympathoadrenal effects of cocaine. Changes in systolic and diastolic blood pressure, heart rate and plasma catecholamine concentrations were determined in response to cocaine injected i.a. or i.c.v. in conscious unrestrained rats. Systemically administered cocaine produced brisk, transient dose-related increases in systolic and diastolic pressure at doses of 0.05 to 5 mg/kg… CONTINUE READING

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