Role of the cell cycle in the pathobiology of central nervous system trauma.

  title={Role of the cell cycle in the pathobiology of central nervous system trauma.},
  author={Ibolja Cernak and Bogdan A Stoica and Kimberly R Byrnes and Simone Di Giovanni and Alan I. Faden},
  journal={Cell cycle},
  volume={4 9},
Upregulation of cell cycle proteins occurs in both mitotic and post-mitotic neural cells after central nervous system (CNS) injury in adult animals. In mitotic cells, such as astroglia and microglia, they induce proliferation, whereas in post-mitotic cells such as neurons they initiate caspase-related apoptosis. We recently reported that early central administration of the cell cycle inhibitor flavopiridol after experimental traumatic brain injury (TBI) significantly reduced lesion volume, scar… CONTINUE READING
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