Role of the carboxyl-terminal lectin domain in self-association of galectin-3.

  title={Role of the carboxyl-terminal lectin domain in self-association of galectin-3.},
  author={Rita Y-T Yang and Paul N. Hill and Daniel Kaiyuan Hsu and F T Liu},
  volume={37 12},
Galectin-3 is a member of a large family of beta-galactoside-binding animal lectins and is composed of a carboxyl-terminal lectin domain connected to an amino-terminal nonlectin part. Previous experimental results suggest that, when bound to multivalent glycoconjugates, galectin-3 self-associates through intermolecular interactions involving the amino-terminal domain. In this study, we obtained evidence suggesting that the protein self-associates in the absence of its saccharide ligands, in a… CONTINUE READING


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