Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis.

@article{Tegtmeyer2011RoleOT,
  title={Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis.},
  author={Nicole Tegtmeyer and Silja Wessler and Steffen Backert},
  journal={The FEBS journal},
  year={2011},
  volume={278 8},
  pages={1190-202}
}
Helicobacter pylori is a very successful human-specific bacterium worldwide. Infections of the stomach with this pathogen can induce pathologies, including chronic gastritis, peptic ulcers and even gastric cancer. Highly virulent H. pylori strains encode the cytotoxin-associated gene (cag)-pathogenicity island, which expresses a type IV secretion system (T4SS). This T4SS forms a syringe-like pilus structure for the injection of virulence factors such as the CagA effector protein into host… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

Similar Papers

Loading similar papers…